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. 2017 May 4;36(12):1653–1668. doi: 10.15252/embj.201695597

Figure 4. Ultrastructural analysis of ZIKV‐infected HeLa cells.

Figure 4

  1. Transmission electron microscopy (TEM) of non‐infected HeLa sh‐IFITM3 cells.
  2. TEM of ZIKV‐infected HeLa sh‐IFITM3 cells at 24 h pi displays cytoplasmic vacuolization (indicated with the letter V) and active virion production (enlarged on the right).
  3. Examples of ZIKV‐infected cells exhibiting large vacuoles.
  4. Enlarged views of dilated nuclear membranes in ZIKV‐infected cells.
Data information: White arrows indicate the “membranous web” associated with viral production and/or accumulation.