Table 1.
Biodistribution of [18F]T808 and [18F]T807 in Normal Mice at 2, 10, 30, and 60 Minutes PI.
| %ID/ga | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Body part | [18F]T808 | [18F]T807 | |||||||
| 2 min | 10 min | 30 min | 60 min | 2 min | 10 min | 30 min | 60 min | ||
| Blood | 1.8 ± 0.1 | 2.0 ± 0.2 | 1.5 ± 0.1 | 0.7 ± 0.1 | 1.5 ± 0.2 | 0.7 ± 0.0 | 0.7 ± 0.1 | 0.6 ± 0.1 | |
| Bone | 2.6 ± 0.6 | 4.2 ± 0.6 | 10.2 ± 2.8 | 9.2 ± 6.1 | 0.1 ± 0.1 | 1.4 ± 0.2 | 0.0 ± 0.0 | 0.1 ± 0.0 | |
| Brain | 4.9 ± 0.5 | 0.9 ± 0.3 | 0.4 ± 0.0 | 0.3 ± 0.0 | 7.5 ± 1.1 | 2.6 ± 0.5 | 0.8 ± 0.4 | 0.4 ± 0.2 | |
| Cerebellum | 5.2 ± 0.5 | 1.0 ± 0.6 | 0.6 ± 0.1 | 0.5 ± 0.2 | 8.5 ± 1.4 | 2.4 ± 0.5 | 0.8 ± 0.4 | 0.4 ± 0.2 | |
| Cerebrum | 4.9 ± 0.5 | 1.0 ± 0.1 | 0.4 ± 0.0 | 0.2 ± 0.0 | 7.2 ± 1.0 | 2.6 ± 0.5 | 0.8 ± 0.4 | 0.4 ± 0.2 | |
| Heart | 3.2 ± 0.4 | 2.3 ± 0.3 | 1.7 ± 0.0 | 0.8 ± 0.1 | 6.8 ± 0.9 | 2.1 ± 0.3 | 1.3 ± 0.3 | 1.0 ± 0.1 | |
| Kidneys | 26.3 ± 1.7 | 12.7 ± 1.7 | 9.2 ± 2.3 | 3.6 ± 1.7 | 35.9 ± 6.2 | 25.6 ± 3.0 | 15.8 ± 5.0 | 13.0 ± 2.6 | |
| Liver | 11.8 ± 2.4 | 15.1 ± 1.6 | 8.3 ± 1.2 | 4.2 ± 0.7 | 12.6 ± 2.4 | 14.6 ± 1.0 | 20.7 ± 1.8 | 18.1 ± 2.2 | |
| Lungs | 4.8 ± 0.6 | 3.0 ± 0.3 | 1.8 ± 0.2 | 0.9 ± 0.2 | 25.1 ± 11.9 | 4.2 ± 1.8 | 3.9 ± 1.2 | 2.1 ± 0.7 | |
| Muscle | 1.5 ± 0.5 | 1.0 ± 0.2 | 0.8 ± 0.1 | 3.5 ± 5.5 | 3.0 ± 1.8 | 1.4 ± 0.3 | 0.6 ± 0.1 | 0.5 ± 0.1 | |
| Pancreas | 7.3 ± 2.4 | 4.0 ± 2.0 | 2.2 ± 0.5 | 1.2 ± 0.3 | 4.1 ± 2.2 | 4.7 ± 0.7 | 2.1 ± 0.8 | 1.5 ± 0.6 | |
| Spleen | 16.6 ± 6.7 | 4.9 ± 0.6 | 2.4 ± 0.4 | 1.3 ± 0.3 | 15.7 ± 5.1 | 13.8 ± 12.5 | 3.8 ± 1.3 | 3.1 ± 1.7 | |
| 2/60 min | 2/60 min | ||||||||
| Brain | 18.2 | 18.3 | |||||||
| Blood | 2.7 | 2.5 | |||||||
Abbreviations: PI, postinjection; SD, standard deviation.
a Percentage of injected dose/gram, calculated as: (counts per minute in body part/sum of counts per minute in all body parts)/(weight of the individual organ). Data are expressed as mean ± SD; n = 4 per time point.