Table 3.
Percentage Blocking of Tracer Binding for [18F]T808, [18F]T807, and [11C]PiB in the Presence of Several Compounds With Affinity for tau or Aβ.
| Group | Compound (1 µmol/L) | nmol/L Tracer (18F + 19F / 11C + 12C) | % Block ± SD (n = 3)a |
|---|---|---|---|
| 1 | T807 | 28 [18F]T807 | 88 ± 0.0 |
| T808 | 7 [18F]T808 | 89 ± 0.0 | |
| T807 | 7 [18F]T808 | 94 ± 0.0 | |
| T808 | 28 [18F]T807 | 90 ± 10b | |
| BF-158 | 40 [18F]T808 | 93 ± 0.0 | |
| BF-170 | 40 [18F]T808 | 84 ± 0.1 | |
| Lansoprazole | 40 [18F]T808 | 4 ± 0.5 | |
| Astemizole | 40 [18F]T808 | 22 ± 0.4 | |
| PiB | 7 [18F]T808 | 19 ± 0.1 | |
| THK5105 | 7 [18F]T808 | 78 ± 0.0 | |
| 2 | TAU1 | 7 [18F]T808 | 75 ± 0.1 |
| TAU2 | 10 [18F]T808 | 48 ± 0.0 | |
| TAU3 | 10 [18F]T808 | 29 ± 0.1 | |
| TAU4 | 10 [18F]T808 | 47 ± 0.0 | |
| TAU5 | 10 [18F]T808 | 73 ± 0.0 | |
| TAU6 | 10 [18F]T808 | 94 ± 0.0 | |
| TAU7 | 7 [18F]T808 | 91 ± 0.0 | |
| TAU8 | 43 [18F]T808 | 90 ± 0.0 | |
| 3 | PiB | 13 [11C]PiB | 57 ± 0.0 |
| T807 | 13 [11C]PiB | 11 ± 0.1 | |
| T808 | 66 [11C]PiB | 17 ± 0.0 | |
| TAU6 | 13 [11C]PiB | 0 ± 0.1 | |
| TAU7 | 13 [11C]PiB | 0 ± 0.0 | |
| TAU8 | 13 [11C]PiB | 0 ± 0.1 |
Abbreviations: Aβ, amyloid β; DLU/mm2, digital light units per square mm; SD, standard deviation.
a Calculated as (DLU/mm2 in the presence of 1 µmol/L blocker) / (DLU/mm2 tracer only).
b SD values of three different experiments. Other SD values are on three different slices in one and the same experiment.