Viral glycoprotein processing inhibition
Iminosugar and target; concentration	INFV strain	Cell line	Virion production or infectivity inhibition	Reference
1-deoxymannojirimycin (DMJ), targeting mannosidase I
1 mM	A/chick/Germany/49 (H10N7)	MDCK	HA expression unaffected	Burke et al. (1984)
			Infectivity (slight). No effect on production
2, 10, 25 μg/ml	A/NWS/33 (H1N1)	MDCK	High-mannose oligosaccharide processing and complex chain formation	Elbein et al. (1984a)
			No effect on hemagglutination
25 μg/ml plus 100 μg/ml CAST	A/NWS/33 (H1N1)	MDCK	No inhibition of oligosaccharide processing (CAST concentration too low to inhibit α-glucosidases)
			Not tested
0.25, 0.5, 1, 2, 4 mM	A/Puerto Rico/8/34 (H1N1)	MDCK	Mannose incorporation (50% at >2 mM)
			Not tested
0.05, 0.1, 0.25, 0.5, 1, 2, 4 mM	A/Puerto Rico/8/34 (H1N1)	CEC	Mannose incorporation
			Not tested
1, 10, 50 μg/ml	Unknown	MDCK	Unaffected	Elbein et al. (1990)
			Not tested
1,4-dideoxy-1,4-imino-d-mannitol (DIM), targeting mannosidase I and II
10, 100, 250 μg/ml	A/NWS/33 (H1N1)	MDCK	High-mannose oligosaccharide processing	Palamarczyk et al. (1985)
			Not tested
Kifunensine, targeting mannosidase I
10, 100 ng/ml 1, 10 μg/ml	Unknown	MDCK	High-mannose oligosaccharide processing and complex chain formation	Elbein et al. (1990)
			Not tested
0.18 mM	A/Puerto Rico/8/34/MS (H1N1)	MDCK	HA sulfation	Karaivanova & Spiro (1998)
			Not tested
0.18 mM	A/Puerto Rico/8/34/MS (H1N1)	LLC-PK1	HA sulfation
			Not tested
N-benzyl-1,5-dideoxy-1,5-imino-d-mannitol, targeting mannosidases
10 mM	A/fowl plague virus/Rostock/34 (H7N1)	MDCK	Not tested	Huang et al. (1991)
			Haemagglutination and CPE
N-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-d-mannitol, targeting mannosidases
10 mM	A/fowl plague virus/Rostock/34 (H7N1)	MDCK	Not tested	Huang et al. (1991)
			Haemagglutination and CPE
3-episiastatin B, targeting NA
10, 20, 40, 100 μM	A/Fort Monmouth/1/47 (H1N1)	MDCK	IC50 = 74 μM for NA	Nishimura et al. (1993)
			PFU 11.1% of control at 40 μM
100 μM	A/Kayano/57 (H2N2)	MDCK	IC50 > 10 μM for NA
			Not tested
100 μM	B/Lee/40	MDCK	IC50 = 42 μM for NA
			Not tested
N-nonyl-deoxygalactonojirimycin (NN-DGJ), targeting ceramide-specific glucosyltransferase
Titration	A/Udorn/307/72 (H3N2)	MDCK	Not tested	Hussain et al. (2015)
			HA titer 117 ± 19%, viral titer 97 ± 20%, plaque number 74 ± 16% and plaque size 88 ± 20% of control at 62.5 μM
Titration	A/Brisbane/10/2007 (H3N2)	MDCK	Not tested
			HA titer 75 ± 15%, viral titer 71 ± 21%, plaque number 60 ± 10% and plaque size 76 ± 4% of control at 62.5 μM
Titration	A/Lviv/N6/2009 (H1N1)	MDCK	Not tested
			HA titer 60 ± 10%, viral titer 85 ± 16% and plaque number 73 ± 8% of control at 62.5 μM. No effect on plaque size