Table 4.
Significant allelic association of SNPs at 11q23.3 chromosomal region with dyslipidemia: Odds ratios from logistic regression of dyslipidemia on variant alleles, before and after adjusting for age, sex and BMI
| SNP ID | Gene/Functional relevance | Alleles Minor/Major |
Minor Allele Frequency | Unadjusted | Adjusted for Age, Sex and BMI | |||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR | p-value | OR | p-value | |||
| rs17440396 | BUD13/Intronic | A/G | 0.24 | 0.18 | 1.4(1.04–1.98) | 0.025 | 1.5(1.08–2.18) | 0.015 |
| rs10488699 | A/G | 0.23 | 0.17 | 1.4(1.03–1.98) | 0.031 | 1.5(1.04–2.03) | 0.029 | |
| rs2187126a | G/A | 0.19 | 0.09 | 2.2(1.50–3.25) | 4.07 × 10−5 | 2.3(1.52–3.41) | 6.04 × 10−5 | |
| rs6589566 | ZPR1/Intronic | G/A | 0.20 | 0.29 | 0.6(0.46–0.86) | 0.003 | 0.7(0.5–0.91) | 0.009 |
| rs633389a | APOA5-A4/Intergenic | T/C | 0.22 | 0.12 | 2.1(1.47–3.02) | 3.72 × 10−5 | 2.0(1.41–2.87) | 0.0001 |
| rs672143 | G/A | 0.00 | 0.03 | 0.1(0.01–0.63) | 0.002 | 0.1(0.01–0.72) | 0.022 | |
| rs1263163a | A/G | 0.30 | 0.14 | 2.6(1.86–3.57) | 7.16 × 10−9 | 3.1(2.15–4.52) | 2.19 × 10−9 | |
| rs1263171 | A/G | 0.48 | 0.40 | 1.4(1.07–1.82) | 0.013 | 1.3(1.03–1.72) | 0.024 | |
| rs2854116 | APOC3/upstream 2 kb | A/G | 0.40 | 0.48 | 0.7(0.54–0.97) | 0.032 | 0.7(0.56–0.98) | 0.038 |
| rs632153 | APOA1/upstream 2 kb | T/G | 0.04 | 0.02 | 2.2(1.04–4.84) | 0.035 | 2.4(1.08–5.22) | 0.030 |
Bold indicates risk increasing nature of the minor allele
aSignificant after correction for multiple testing