FIG. 3.
Effect of human affinity-purified anti-MSP6 antibodies on parasite growth in ADCI assays. The histograms represent mean values of percent SGI (as explained in the text) from three independent experiments ± standard error; values >30% were considered significant. PIAG, positive control IgG from the pool of Ivory Coast adult sera used for passive transfer in humans (10). The level of parasite inhibition obtained with affinity-purified antibodies was adjusted in proportion to the effect observed by PIAG, which was considered to be 100%. NIgG, negative control IgG from pool of French donors not exposed to malaria. Anti-RESA antibodies were affinity purified from a pool of hyperimmune sera (Ivory Coast) against a synthetic peptide (sequence H-[EENVEHDA]2-[EENV]2-OH).