Figure 2. Association Between Nonadherence to First-Year Fixed-Dose Combination Inhaled Corticosteroid/LABA Therapy and COPD Exacerbations Rate.

^aAdherent, proportion of days covered (PDC) ≥0.8; mildly nonadherent, 0.5 ≤ PDC <0.8; moderately nonadherent, 0.3 ≤ PDC <0.5; highly nonadherent, PDC <0.3.

CI indicates confidence interval; COPD, chronic obstructive pulmonary disease; LABA, long-acting ß₂-adrenergic agonist.