Table 3.
Among children with the upper tertile of exposure to BC, physical activity is associated with reduced lung function, whereas children with less BC exposure experience opposite effects
| Difference in methylation in active vs. non-active children β estimate (95% confidence interval) |
||||
|---|---|---|---|---|
| Overall sample (n = 135) | Upper tertile BCa
(n = 33) |
Lower 2/3 BCa
(n = 102) |
p interaction | |
| FEV1 | 2.72 (−1.14, 6.59) | −7.87 (−15.33, −0.42) | 4.60 (0.21, 8.99) | 0.09 |
| FVC | 1.25 (−2.25, 4.75) | −6.91 (−13.70, −0.13) | 2.70 (−1.30, 6.70) | 0.31 |
| FEV1/FVC | 1.36 (−0.62, 3.33) | −1.09 (−5.03, 2.5) | 1.90 (−0.49, 4.28) | NA |
| FEF25−75% | 8.07 (0.40, 15.74) | −6.59 (−23.0, 9.80) | 9.60 (0.60, 18.60) | 0.27 |
β estimate represents the effect size or the difference in percent methylation when comparing active children to non-active children (reference). Models adjusted for age, sex, race/ethnicity, BMI Z-score, asthma, atopy, secondhand smoke exposure, heating season, and BC concentration (only for overall sample model). Italicized values represent p value ≤0.05. P interaction represents the p value for the interaction term between physical activity and BC
aDichotomized at the upper tertile, 1790 ng/m3