Table 5.
Odds ratio of breast cancer risk associated with serum levels of OCPs
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Continuous (μg/kg lipid) |
Continuous (μg/kg lipid) |
1st Tertile | 2nd Tertile | 3rd Tertile | |
| ∑OCP (OR (95% CI)) | 1.00 | 1.00 (1.00; 1.00) | 1.00 (reference) | 1.05 (0.47; 2.39) | 1.90 (0.88; 4.07) |
| n (cases/controls) | 75/84 | 75/84 | 19/28 | 20/28 | 36/28 |
| p-value | 0.002 | 0.002 | 0.902 | 0.101 | |
| Cis-Nonachlor (OR (95% CI)) | 1.01 | 1.01 (1.00; 1.01) | 1.00 (reference) | 1.31 (0.58; 2.96) | 2.07 (0.96; 4.47) |
| n (cases/controls) | 76/84 | 76/84 | 18/29 | 22/27 | 36/28 |
| p-value | 0.008 | 0.008 | 0.512 | 0.063 | |
| Trans-Nonachlor (OR (95% CI)) | 1.00 | 1.00 (1.00; 1.00) | 1.00 (reference) | 1.00 (0.44; 2.25) | 1.80 (0.84; 3.84) |
| n (cases/controls) | 76/84 | 76/84 | 20/28 | 20/28 | 36/28 |
| p-value | 0.002 | 0.002 | 1.000 | 0.128 | |
| HCB (OR (95% CI)) | 1.00 | 1.00 (1.00; 1.00) | 1.00 (reference) | 0.86 (0.38; 1.94) | 1.76 (0.83; 3.73) |
| n (cases/controls) | 76/84 | 76/84 | 21/28 | 23/28 | 32/28 |
| p-value | 0.062 | 0.062 | 0.712 | 0.138 | |
| Mirex (OR (95% CI)) | 1.01 | 1.01 (1.00; 1.02) | 1.00 (reference) | 1.42 (0.65; 3.12) | 1.58 (0.73; 3.44) |
| n (cases/controls) | 76/84 | 76/84 | 19/28 | 27/28 | 30/28 |
| p-value | 0.026 | 0.026 | 0.381 | 0.250 | |
| Oxychlordane (OR (95% CI)) | 1.00 | 1.00 (1.00; 1.00) | 1.00 (reference) | 1.11 (0.49; 2.49) | 1.90 (0.88; 4.07) |
| n (cases/controls) | 76/84 | 76/84 | 19/28 | 21/28 | 36/28 |
| p-value | 0.005 | 0.005 | 0.809 | 0.101 | |
| p,p’DDE (OR (95% CI)) | 1.00 | 1.00 (1.00; 1.00) | 1.00 (reference) | 1.69 (0.75; 3.80) | 2.06 (0.93; 4.56) |
| n (cases/controls) | 76/84 | 76/84 | 16/28 | 27/28 | 33/28 |
| p-value | 0.002 | 0.002 | 0.206 | 0.074 | |
| p,p’DDT (OR (95% CI)) | 1.01 | 1.01 (1.00; 1.03) | 1.00 (reference) | 1.52 (0.67; 3.42) | 2.07 (0.95; 4.52) |
| n (cases/controls) | 75/84 | 75/84 | 17/29 | 24/27 | 34/28 |
| p-value | 0.074 | 0.074 | 0.315 | 0.067 | |
| βHCH(OR (95% CI)) | 1.01 | 1.01 (1.00; 1.03) | 1.00 (reference) | 1.11 (0.49; 2.49) | 1.90 (0.88; 4.07) |
| n (cases/controls) | 76/84 | 76/84 | 19/28 | 21/28 | 36/28 |
| p-value | 0.071 | 0.071 | 0.809 | 0.101 | |
n: number of observations per group; OR: odds ratio; 95% CI: 95% confidence interval; Unadjusted analysis: Only OR, and not 95% CI, were reported for unadjusted data; Adjusted: adjusted for confounders identified by change in estimate, following confounders were considered age, BMI, cotinine levels, parity, and breastfeeding; Bold text: significant finding, OR significantly different from 1; ∑OCP: p,p′-DDT, p,p′-DDE, mirex, β-HCH, HCB, cis- and trans-nonachlor, and oxychlordane