Table 1. Antenatal and Perinatal Characteristics of the Cohort of Extremely Preterm Infants With Clinically and Echocardiographically Significant Patent Ductus Arteriosus.
| Characteristic | No. (%) | Difference (95% CI) | P Valuea | |
|---|---|---|---|---|
| Surgical Ligation (n = 184) |
Medical Treatment Only (n = 570) |
|||
| GA, mean (SD), wk | 25.2 (1.1) | 25.9 (1.2) | −0.7 (−0.87 to −0.48) | <.001 |
| BW, mean (SD), g | 742 (163) | 835 (183) | −93 (−125 to −66) | <.001 |
| SGA, <10th percentile | 29 (15.8) | 63 (11.0) | 4.8% (−1.1 to 10.6) | .09 |
| Initial level 3 hospital | NA | .39 | ||
| SB | 74 (25.5) | 216 (74.5) | ||
| MSH | 79 (22.4) | 273 (77.6) | ||
| HSC | 31 (27.7) | 81 (72.3) | ||
| Multiple gestation | 54 (29.3) | 200 (35.1) | −6.8% (−13.4 to 1.9) | .19 |
| Male | 86 (46.7) | 322 (56.5) | −9.8% (−18.0 to −1.4) | .02 |
| Antenatal corticosteroids, full | 95 (51.6) | 317 (55.6) | −4.0% (−12.3 to 4.3) | .38 |
| Vaginal delivery | 94 (51.1) | 286 (50.2) | 0.9% (−7.4 to 9.2) | .87 |
| Not born at institution | 56 (30.4) | 161 (28.2) | 2.2% (−5.4 to 9.8) | .58 |
| Intensive delivery room resuscitationb | 181 (98.4) | 531 (93.2) | 5.2% (2.4-8.0) | .007 |
| 5-min Apgar <7 | 78 (42.4) | 217 (38.1) | 4.3% (−3.0 to 12.5) | .30 |
| Indomethacin prophylaxis | 48 (26.1) | 101 (17.7) | 8.4% (1.3-15.4) | .02 |
| SNAPII score ≥20 | 73 (39.7) | 187 (32.8) | 6.9% (−1.2 to 14.9) | .09 |
Abbreviations: BW, birth weight; GA, gestational age; HSC, Hospital for Sick Children; MSH, Mount Sinai Hospital; NA, not applicable; SB, Sunnybrook Health Sciences Centre; SGA, small for gestational age; SNAPII, score for neonatal acute physiology II.
a
t-test or Wilcoxon test for continuous data, or χ2 test for categorical data.
b
Defined as intubation, chest compressions, or epinephrine administration.