Table 3. Odds Ratio (OR) of Optimal Adherence, by Patient Subgroup.
| Patient Subgroup | vs Control, OR (95% CI) | |||||
|---|---|---|---|---|---|---|
| Standard Pillbox | P Value | Digital Timer Cap | P Value | Pill Bottle Strip With Toggles | P Value | |
| Age, y | ||||||
| <50 | 1.05 (0.99-1.12) | .67 | 0.99 (0.92-1.06) | .40 | 1.00 (0.91-1.09) | .12 |
| ≥50 | 1.03 (0.96-1.10) | 1.03 (0.96-1.09) | 0.91 (0.84-0.98) | |||
| Sex | ||||||
| Female | 1.04 (0.98-1.11) | .98 | 1.04 (0.98-1.11) | .15 | 0.86 (0.79-0.93) | <.001 |
| Male | 1.04 (0.99-1.09) | 1.01 (0.96-1.06) | 0.95 (0.90-1.01) | |||
| Prerandomization adherence | ||||||
| Lower adherence (MPR <0.55) | 1.05 (0.98-1.12) | .80 | 0.96 (0.90-1.03) | .02 | 0.99 (0.91-1.08) | .23 |
| Higher adherence (MPR ≥0.55) | 1.04 (0.97-1.11) | 1.07 (1.01-1.15) | 0.92 (0.85-1.00) | |||
| No. of targeted medications | ||||||
| 1 | 1.01 (0.94-1.09) | 1.01 (0.93-1.09) | 0.99 (0.91-1.09) | |||
| 2 | 1.06 (0.97-1.16) | .34a | 1.04 (0.95-1.14) | .52a | 0.91 (0.81-1.02) | .11a |
| 3 | 0.94 (0.77-1.15) | .29a | 0.99 (0.81-1.21) | .77a | 1.15 (0.90-1.46) | .09a |
Abbreviation: MPR, medication possession ratio.
a
Compared with 1 targeted medication.