Table 2. Association Between Each BP Component at Y0 and CVD Risk: Race-Specific HRs and Changes in Model Fit and Discrimination for Incident CVD Eventsa.
| Component | Black Individuals (n = 2473) |
White Individuals (n = 2407) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) Per 1 SD of BP Component | Likelihood Ratio χ2b | AIC | BIC | C Statistics (95% CI)b | HR (95% CI) Per 1 SD of BP Component | Likelihood Ratio χ2a | AIC | BIC | C Statistics (95% CI)b | |
| Base model | NA | 104.62 | 2006.55 | 2076.31 | 0.694 (0.636-0.752) | NA | 93.71 | 987.22 | 1056.66 | 0.735 (0.650-0.820) |
| Base model plus single BP measurement (Y0) | ||||||||||
| SBP | 1.36 (1.14-1.61)c | 115.51d | 1997.66 | 2073.23 | 0.707 (0.642-0.772) | 1.16 (0.88-1.53) | 94.77 | 988.16 | 1063.38 | 0.733 (0.649-0.818) |
| DBP | 1.19 (0.99-1.41) | 108.48e | 2004.69 | 2080.26 | 0.699 (0.637-0.760) | 1.54 (1.17-2.03)c | 103.08c | 979.85 | 1055.07 | 0.746 (0.664-0.828) |
| MAP | 1.28 (1.08-1.51)e | 112.29 | 2000.87 | 2076.45 | 0.702 (0.638-0.766) | 1.42 (1.09-1.85)c | 104.46c | 982.47 | 1057.69 | 0.742 (0.659-0.824) |
| PP | 1.10 (0.95-1.28) | 106.21c | 2006.96 | 2082.53 | 0.697 (0.639-0.755) | 0.73 (0.54-0.99)e | 97.97e | 984.96 | 1060.18 | 0.742 (0.659-0.824) |
| Base model plus dual BP measurement (Y0) | ||||||||||
| Model 1 | ||||||||||
| SBP | 1.32 (1.09-1.61)b | 115.79c | 1999.38 | 2080.76 | 0.707 (0.642-0.772) | 0.82 (0.57-1.18) | 104.19c | 980.74 | 1061.75 | 0.748 (0.667-0.829) |
| DBP | 1.05 (0.88-1.26) | NA | NA | NA | NA | 1.74 (1.21-2.50)c | NA | NA | NA | NA |
| Model 2 | ||||||||||
| MAP | 1.31 (1.11-1.55)c | 115.79d | 1999.38 | 2080.77 | 0.707 (0.642-0.772) | 1.40 (1.08-1.83)e | 104.19c | 980.73 | 1061.74 | 0.748 (0.667-0.829) |
| PP | 1.17 (0.99-1.36) | NA | NA | NA | NA | 0.74 (0.54-1.01) | NA | NA | NA | NA |
Abbreviations: AIC, Akaike information criterion; BIC, Bayes information criteria; BP, blood pressure; CVD, cardiovascular disease; DBP, diastolic blood pressure; HR, hazard ratio; MAP, mean arterial pressure; NA, not applicable; PP, pulse pressure; SBP, systolic blood pressure; Y0, year 0.
Race-specific adjusted HRs (95% CIs) for risk of incident CVD with a 1-SD increment in SBP, DBP, MAP, and PP are shown. A 1-SD increment of each BP parameter at Y0 is as follows: SBP, 11 mm Hg; DBP, 10 mm Hg; MAP, 9 mm Hg; and PP, 10 mm Hg. Base model includes the following sociodemographic characteristics: age, sex, educational level, and study site (Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California). The following clinical characteristics were included at Y0: smoking, body mass index, fasting glucose level, total cholesterol and high-density lipoprotein cholesterol levels, and antihypertensive medication use. Statistical significance was defined as P < .05.
The differences from base model were statistically tested. The Harrell C was used to calculate C statistics.
P < .01.
P < .001.
P < .05.