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. Author manuscript; available in PMC: 2017 Jun 14.
Published in final edited form as: Biochem Soc Trans. 2014 Oct;42(5):1383–1388. doi: 10.1042/BST20140187

Figure 4.

Figure 4

Schematic model pose representation of an active NPPM in complex with Sec14. Figure shows NPPM-481 rendered in ball and stick mode, and inhibitor binding is stabilized via a network of halogen bond and hydrogen bond interaction with residue Ser173. Magnified figure shows the electrostatic potential (ESP) mapped over molecular surface of chloro-nitrophenyl moiety of NPPM-481, and illustrates the halogen-bonding interaction with Ser173 via an electro-positive a σ-hole on the chlorine moiety (see Nile et al., 2014).