Table 1.
Accuracy of the approaches (a)–(d) to discriminate between methicillin-resistant and methicillin-susceptible Staphylococcus aureus.
| Approach | (a) | (b) | (c) | (d) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Min. | SE (%) | (95% CI) | SP (%) | (95% CI) | SE (%) | (95% CI) | SP (%) | (95% CI) | SE (%) | (95% CI) | SP (%) | (95% CI) | SE (%) | (95% CI) | SP (%) | (95% CI) |
| 60 | 84 | (70.9–92.8) | 48 | (33.7–62.6) | 52 | (37.4–66.3) | 78 | (64–88.5) | 66 | (51.2–78.8) | 64 | (49.2–77.1) | 48 | (33.7–62.6) | 76 | (61.8–86.9) |
| 120 | 82 | (68.6–91.4) | 80 | (66.3–90) | 80 | (66.3–90) | 88 | (75.7–95.5) | 78 | (64–88.5) | 84 | (70.9–92.8) | 68 | (53.3–80.5) | 90 | (78.2–96.7) |
| 180 | 100 | (92.9–100) | 94 | (83.5–98.7) | 86 | (73.3–94.2) | 98 | (89.4–99.9) | 98 | (89.4–99.9) | 96 | (86.3–99.5) | 84 | (70.9–92.8) | 100 | (92.9–100) |
| 240 | 100 | (92.9–100) | 100 | (92.9–100) | 94 | (83.5–98.7) | 94 | (83.5–98.7) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) |
| 300 | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) | 100 | (92.9–100) |
| 360 | 100 | (91.6–100) | 98 | (89.4–99.9) | 100 | (91.6–100) | 98 | (89.4–99.9) | 100 | (91.6–100) | 98 | (89.4–99.9) | 100 | (91.6–100) | 100 | (92.9–100) |
SE, Sensitivity; SP, Specificity; (a) Discrimination based on concentrations, (b) Discrimination based on ratios of concentrations (sample with antibiotics vs. growth control), (c) Discrimination based on concentration slopes, (d) Discrimination based on ratios of concentration slopes (sample with antibiotics vs. growth control).