Table 2.
Modality | p-Value (FWE-corrected) | Cluster extent (voxels) | Z score | Coordinates (mm) |
Anatomical location | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
Jacobian determinant (i.e. volume loss) | 0.017 | 336 | 3.87 | 0 | − 39 | − 49 | Cluster spanning the CSTs and medial lemniscus (medulla) |
MT (i.e. myelin reduction) | 0.001 | 15 | 4.32 | 1 | − 28 | − 4 | PAG |
0.039 | 8 | 4.5 | − 2 | − 38 | − 54 | CST (L, medulla) | |
R1 (i.e. myelin reduction) | < 0.001 | 110 | 4.78 | − 8 | − 38 | − 27 | Low-mid pons (L, dorsolateral) |
0.019 | 21 | 3.77 | − 8 | − 40 | − 29 | Low-mid pons (L, dorsolateral) | |
0.006 | 18 | 3.66 | 9 | − 43 | − 31 | Low pons (R, dorsolateral) | |
0.01 | 16 | 4.07 | 2 | − 41 | − 34 | Low pons (dorsomedial) | |
0.005 | 7 | 3.85 | 4 | − 42 | − 35 | Low pons (R, dorsomedial) | |
0.011 | 4 | 3.55 | − 2 | − 41 | − 36 | Low pons (L, dorsomedial) | |
0.024 | 2 | 3.41 | − 1 | − 39 | − 36 | Low pons (L, dorsomedial) | |
0.038 | 1 | 3.18 | 6 | − 44 | − 37 | Pontomedullary junction (R, dorsolateral) | |
0.02 | 13 | 3.82 | 2 | − 43 | − 39 | Pontomedullary junction (R, dorsomedial) | |
< 0.001 | 485 | 5.11 | − 7 | − 44 | − 48 | Medulla (bilateral, dorsal) | |
0.025 | 12 | 4.99 | 4 | − 35 | − 49 | CST (R, medulla) | |
0.003 | 22 | 4.53 | − 1 | − 38 | − 54 | CSTs (bilateral, medulla) |
CST = corticospinal tract, FWE = family-wise error, L = left, MT = magnetisation transfer saturation, PAG = periaqueductal grey, R = right, R1 = longitudinal relaxation rate.