Table 2.
Median # per 105 PBMC (IQR) | |||||||
---|---|---|---|---|---|---|---|
Total Absolute EPCs | Week 0 | Week 6 | 6-Week Fold Change | p | Week 12*† | 12-Week Fold Change | p |
Glycophorin−/CD133+/KDR+ | 8.0 (2.7, 112.4) |
82.8 (11.3, 188.2) |
1.8 | 0.02 | 89.2 (17.6, 159.9) |
1.7 | 0.08 |
CD34+/CD133+ | 33.3 (13.4, 85.5) |
67.2 (31.6, 121.8) |
1.4 | 0.06 | 87.6 (31.2, 128.5) |
1.8 | 0.006 |
CD34+/KDR+ | 1.8 (0.8, 49.6) |
39.5 (2.0, 85.2) |
1.9 | 0.08 | 45.9 (4.1, 77.6) |
1.9 | 0.03 |
CD34+/CD133+/KDR+ | 0.9 (0.3, 48.0) |
38.5 (1.6, 83.9) |
2.0 | 0.04 | 44.1 (3.0, 74.6) |
2.0 | 0.02 |
Within CD34+ EPC Subset | % of CD34+ EPC (IQR) | ||||||
CD133+ | 34.9 (32.5, 46.4) |
37.6 (31.7, 43.1) |
1.0 | 0.91 | 36.4 (25.3, 41.7) | 1.0 | 0.83 |
KDR+ | 5.9 (1.7, 17.4) |
14.8 (2.6, 26.0) |
1.5 | 0.11 | 14.5 (4.9, 20.8) |
1.4 | 0.43 |
CD133+/KDR+ | 4.2 (0.4, 15.2) |
14.4 (2.4, 25.4) |
1.7 | 0.07 | 14.1 (3.1, 19.8) |
1.6 | 0.29 |
One subject excluded for increasing statin dose between weeks 6 and 12
12 subjects off drug
EPC= Endothelial Progenitor Cells, IQR=Interquartile Range, PBMC= Peripheral Blood Mononuclear Cells