TABLE 2.

Functional families overrepresented in the macrophage transcriptional response to late stages of B. anthracis infection

Induced			Repressed
Biological process	P		Biological process	P
Regulation of apoptosis	2.6 E-6		Cell-matrix adhesion	5.0 E-5
Regulation of transcription	1.0 E-5		G-protein coupled receptor protein signaling pathway	3.1 E-4
Nitrogen metabolism	2.0 E-5		Angiogenesis	0.0013
Immune response (inflammatory response)	2.0 E-5		Regulation of cell cycle	0.0100
Regulation of cell cycle	5.0 E-5		Cell adhesion	0.0109
Intracellular signaling cascade	8.0 E-5		Regulation of apoptosis	0.0113
Protein phosphorylation and desphosphorylation	9.0 E-5		Immune response	0.0175
Cytokine biosynthesis	1.2 E-4		Intracellular signaling cascade	0.0212
Amine catabolism	3.8 E-4
Cytoskeleton organization and biogenesis	0.0012
Protein kinase cascade	0.0025
Cell differentiation	0.0026
Cell-matrix adhesion	0.0034
Cell adhesion	0.0039
Receptor-linked signal transduction	0.0094
GTPase-mediated signaling cascade	0.0182
Proteolysis	0.0345