Table 3.
Visual score of DNA damage in male mice exposed to high dose (400 mg/kg) of SiO2, TiO2, and ZrO2-Ps
| Treatment | No. of cells | ClassΩ | DNA damaged cells (% mean) | ||||
|---|---|---|---|---|---|---|---|
| Analysed | Comet | 0 | 1 | 2 | 3 | ||
| Control | 100 | 9 | 91 | 6 | 3 | 0 | 9c |
| Cyclophosphamide | 100 | 29 | 71 | 8 | 7 | 14 | 29a |
| SiO2 | 100 | 10 | 90 | 5 | 4 | 1 | 10c |
| TiO2 | 100 | 19 | 81 | 4 | 6 | 9 | 19b |
| ZrO2 | 100 | 11 | 89 | 5 | 3 | 3 | 11c |
| SiO2 : TiO2 (1 : 1) | 100 | 12 | 88 | 3 | 5 | 4 | 12c |
| SiO2 : TiO2 (1 : 2) | 100 | 15 | 85 | 5 | 4 | 6 | 15bc |
| SiO2 : TiO2 (1 : 3) | 100 | 20 | 80 | 1 | 7 | 12 | 20b |
| SiO2 : ZrO2 (1 : 1) | 100 | 10 | 90 | 4 | 3 | 3 | 10c |
| SiO2 : ZrO2 (1 : 2) | 100 | 12 | 88 | 6 | 2 | 4 | 12c |
| 100 | 14 | 86 | 5 | 4 | 5 | 14bc | |
Ω
: Class 0 = no tail; 1 = tail length < diameter of nucleus; 2 = tail length between 1× and 2× the diameter of nucleus; and 3 = tail length > 2× the diameter of nucleus.