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. 2017 Jun 14;12(6):e0177805. doi: 10.1371/journal.pone.0177805

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© 2017 Bai et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Tamoxifen resistant MCF7 cells (TamR) were plated in 96 well plate overnight before treatment with 10μM Tamoxifen (final concentration is 5μM) for 1h, then treated with LCL521 with the final concentration at 0, 1, 2.5 and 5μM. To compare LCL521 its own killing effect, wild MCF7 cells were plated in 96 well plate at same time and varies dose of LCL521 were treated at the same time. Cells were kept for 48h before MTT assay was preformed. The results are expressed as a percentage of vehicle samples and presented as means ± st dev. of triplicates. * p<0.05 (vs 0); ** p<0.01 (vs 0); *** p<0.001 (TamR vs MCF7).