Table 1.

Key Personal and Family History Elements

	Short Telomere Syndromes
Adult ILD	++
Premature graying*	++
Cryptogenic cirrhosis	++
Aplastic anemia	++
Myelodysplasia/leukemia	+

Definition of abbreviation: ILD = interstitial lung disease.

The presence of two or more features in an individual or family suggests a short telomere syndrome. Other features including osteoporosis, enterocolitis, and nonmelanoma skin cancer are also observed in some individuals and families with short telomere syndromes.

^*Significant graying before age 30 years.