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. 2016 Nov 15;102(6):1797–1806. doi: 10.1210/jc.2016-2855

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 4. — Effect of Chronocort treatment on 24-hour urinary steroid metabolite excretion in patients with CAH due to 21OHD. (A) 17OHP metabolites. (B) 11-deoxycortisol metabolite. (C) Sum of active androgen metabolites. (D) Signature alternative pathway metabolite. (E) Ratio of alternative pathway/total 5α-reduced androgen metabolites. (F) Major 11-oxygenated androgen pathway metabolite. Results are shown for patients with CAH at baseline taking conventional GC therapy prior to commencing Chronocort (BL; n = 16), at day 4 of Chronocort treatment (D4; n = 16), and after 6 months of Chronocort treatment (M6; n = 15). Box-and-whisker plots represent median, interquartile range (box), and 5th and 95th percentiles (whiskers). Analyses were undertaken using repeated Wilcoxon tests with Bonferroni correction to compare between matched patients with CAH. *P ≤ 0.05. PT, pregnanetriol; THS, tetrahydro-11-deoxycortisol.