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. 2017 Jun 14;3(6):e1700731. doi: 10.1126/sciadv.1700731

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Copyright © 2017, The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 1 — (A) In dragons, ZW embryos develop as female (ZWf; blue) regardless of environmental temperature. ZZ embryos develop as male (ZZm; yellow) at low temperatures and as sex-reversed females (ZZf; red) at high temperatures. Because female development can be specified independently by temperature or sex chromosome complement, it is possible to distinguish the effects of temperature and genotype on sex determination. (B) Principal components analysis and (C) Spearman ranked correlation clustering of global gene expression profiles for adult tissues from ZWf, ZZm, and ZZf individuals. (D) Top: Expression of POMC is activated by CRH (13), and CRH is inhibited by CRHBP (15). Bottom: Normalized expression (transcripts per million; mean ± SD; n = 2) for CRH (brain), POMC (brain), and CRHBP (liver) in ZWf, ZZm, and ZZf tissues. (E) Conserved domain prediction (protein BLAST) for the expressed sequence of POMC in dragon.