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. 2017 Jun 15;2(12):e93042. doi: 10.1172/jci.insight.93042

Figure 7. Protective activities of mAbs in AG6 mice.

Figure 7

One day after challenge with 1 × 104 pfu of ZIKV GZ01, AG6 mice were treated with 300 μg mAbs ZK2B10, ZK8-4, or control mAb MERS-4 i.p. and monitored for survival (A), body weight (B) and blood ZIKV RNA (C) up to 14 days. ZK2B10 provided 100% protection against ZIKV diseases, while ZK8-4 and the control MERS-4 failed (***P < 0.001, one-way ANOVA) with an average time of death of 7 and 8 days. The body weight and ZIKV RNA in the whole blood derived from a single measurement showed distinct results among the study groups. The number of animals used in each group (n) is also indicated.