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. 2017 Jun 15;2(12):e94005. doi: 10.1172/jci.insight.94005

Figure 7. NPY expression reemerges in β cells in humans with type 1 and type 2 diabetes.

Figure 7

(A) Pancreatic sections were immunostained from a human donor subject with type 2 diabetes (T2D; LT2-11, Mayo; ~60% β cells positive for NPY) and an age- and BMI-matched control human subject (LND-20, Mayo; ~12% β cells positive for NPY) for NPY (red), somatostatin (SS; green), and insulin (Ins; cyan), along with nuclear counterstaining with DAPI (blue). (B) Immunostaining for NPY (red), somatostatin (green), and insulin (cyan), with DAPI in blue, in pancreatic sections from a donor subject with type 1 diabetes (T1D; 6051, nPOD; ~80% β cells positive for NPY) displaying residual β cells, and an age- and BMI-matched control donor human subject (6057, nPOD; ~14% β cells positive for NPY). Scale bar: 50 μm.