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. 2017 Jun 15;2(12):e92851. doi: 10.1172/jci.insight.92851

Figure 4. Label loss kinetics for Tregs in the liver in allogeneic (allo) hematopoietic stem cell transplant recipients (HSCT) are driven by increased propensity for apoptosis rather than trafficking.

Figure 4

(A) Label loss kinetics for allogeneic liver–derived Treg and Tem cells. Data are representative of 3 independent experiments for day +14 and +28 (n = 5–8 mice per experiment per cohort). (B) Caspase 3 staining for CD4+ Treg and Tem subsets extracted from the spleen and liver at day +14 (n = 5 mice per cohort). (C) The mean total CD4+ T cell number measured in the peripheral blood of each experimental cohort at day +14 and +28. (D) The mean total Tem cell number measured in the peripheral blood of each experimental cohort at day +14 and +28. Data are representative of 4 independent experiments (n = 2–6 mice per experiment per cohort). For panels C and D, **P < 0.01, ***P < 0.001; Tukey’s test with 2-way ANOVA.