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. 2017 Mar 11;8(21):34082–34098. doi: 10.18632/oncotarget.16133

Figure 7. HKL treatment protects the heart from doxorubicin-induced mitochondrial damage in vivo.

Figure 7

A. Heart lysates of Vehicle, Doxo, Doxo plus HKL and HKL alone treated mice were subjected to immunoblotting using indicated antibodies. Representative blot of two different mice in each group are shown, n = 6. (quantification of blots is given in supplement Figure 2). B. Mitochondrial DNA damage was assessed in the whole heart of different group of mice as in panel A. All values are mean ± SE, n = 6. C. 8-Oxo-dG content in the DNA of whole heart of different group of mice. All values are mean ± SE, n = 5. D. Mitochondrial citrate synthase activity in the heart of different group of mice. CS, citrate synthase. Values are mean ± SE, n = 5. E. quantification of ATP contents in the heart lysate of different groups of mice as in panel A. Values are mean ± SE, n = 5.