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. 2017 Mar 11;8(21):34082–34098. doi: 10.18632/oncotarget.16133

Figure 8. HKL treatment protected mouse hearts without affecting the anti-cancer potency of doxorubicin.

Figure 8

A. Representative images of mice implanted with PC3 cells and subjected to treatment with vehicle (control), Doxo, Doxo plus HKL and HKL alone. B. Tumor growth rate in mice of different treatment groups. C. Development of hypertrophy as measured by heart weight to tibia length (HW/TL) ratio in different treatments group of mice. values are mean ± SE, n = 8-10. D. Echocardiographic measurements of fractional shortening in mice. Values are mean ± SE, n = 8-10. E. Representative heart sections stained with Masson's trichrome to detect fibrosis (blue); scale bars, 20 µm.F. Quantification of cardiac fibrosis in different groups of mice as in panel E. Mean ± SE, n = 5.