Figure 9. Blocking SNAIL substantially inhibited metastasis and CTC formation but not primary tumor growth.

(A) The effect of SNAIL silencing on primary tumor growth, formation of metastasis, and CTC counts at the completion of the experiment (Treatment Day 33). Control versus a doxycycline-induced SNAIL knockdown arm. (B) CTCs were assessed in blood collected from a terminal cardiac puncture (Mean ± SEM) and were significantly inhibited following SNAIL knockdown.