Figure 2. The schematic protocol for stepwise bioinformatics identifying the 17 skin-related keloid-aberrant Wnt-genes.

(A) Identification of the 116 differentially expressed genes involved in Wnt signalling pathway in keloids compared to adjacent normal skin using microarray detection. (B) Identification of the 114 dermis-related Wnt-genes by the online Human Phenotype Enrichment from the previous published documents. Based on (A and B), the overlapped 17 skin-related array-aberrant genes involved in Wnt pathway were identified using Venn graphing. (C) The number on each of the column indicate how many dermis diseases the gene has been enriched in the previous publication.