Figure 3. The co-expression coefficient (CC) of the 17 skin-related Wnt-genes (Green Dots) interacting to 11 top co-expressed lncRNAs (Yellow Dots) was in-pair illustrated in the Figure 3.

In Supplementary Table 2, the co-expressed lncRNA/gene pair profiles were listed and ranked by CC values, thus the 11 lncRNAs characterized with the top CC to each of the 17 skin-related gene can be identified. Among them, four lncRNAs exhibited overlapped top CC to distinct Wnt-genes (shared Top CC). Notably, among these 11 top interactive lncRNAs, only 7 lncRNAs (Marked by Bold*) displayed significantly alteration due to array detection in keloids. Reversely, the 12 skin-related Wnt-genes (marked by **) were identified as their paired genes. In the next step, the 12 lncRNA/gene pairs (molecular pair marked by genes**/lncRNA*) were selected to undergo intracellular qPCR verification.