Figure 5. The right part of the figure depicts the eight functional modules (marked from 1^st to 8^th) of all Wnt-genes using the Weighted Correlation Network Analysis (WGCNA).

The size of each module is in proportion to the number of clustered Wnt-genes (see Supplementary Table 3 for the detailed gene lists of 8 functional modules). The left part of the figure describes the functional module in which each of the 17 skin-related keloid-aberrant Wnt-genes clustered. The directions of the arrows indicate the array-detected up- or down-regulated expression. Generally, among the 8 functional modules involved in Wnt signalling pathway, 6 skin-related Wnt-genes were clustered in the 6^th module (cell surface receptor signalling pathway) which displayed the most clustered module in keloids, followed by 4 skin-related Wnt-genes clustered in the 4^th module (Negative regulation of cellular process).