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. 2017 Mar 7;8(21):34268–34282. doi: 10.18632/oncotarget.15965

Figure 11. Modulation of piRNA expression by Dorsomorphin and Trichostatin.

Figure 11

H1299 lung cancer cells were treated with Dorsomorphin (Dorso) or Trichostatin (Tricho) and the expression of specific piRNAs was assessed. Dorsomorphin treatment increased the expression of piR-34871 and piR-52200 but did not have a significant effect on piR-35127 and piR-46545. Trichostatin A increased the expression of piR-35127 and piR-46545 and decreased the expression levels of piR-34871 and piR-52200. The RT-PCR of control and experimental reactions were run in triplicates in multiple independent runs and the 2-ΔΔ method was used to perform statistical analysis (32). The (*) indicates statistical significance compared to controls (DMSO), with a P < 0.05.