Table 5. Univariate analysis of pMKK4 score and clinicopathological characteristics in the validation-set.

	pMKK4 score				P
	Low score		High score
	negative (–)	weak (+)	moderate (++)	strong (+++)
Gender					0.361
Male	95	70	44	21
Female	97	58	42	11
Age (years)					0.573
< 60	95	57	36	13
≥ 60	97	71	50	19
Tumor Differentiation					0.153
Poof	30	18	8	2
Moderate	147	102	66	28
Well	15	8	12	2
Invasive Depth					< 0.001
T1	1	1	8	1
T2	23	18	18	12
T3	142	92	48	19
T4	26	17	12	0
LN metastasis					< 0.001
Absent	92	64	60	28
Present	100	64	26	4
Distant metastasis(synchronous & metachronous)
Absent	120	87	72	32	< 0.001
Present	72	41	14	0
Liver metastasis(synchronous & metachronous)					< 0.001
Absent	124	90	75	32
Present	68	38	11	0
TNM Stage					< 0.001
I	19	12	18	13
II	63	51	40	15
III	76	58	23	4
IV	34	7	5	0

(N = 438) features.