Table 1. Clinical characteristics and Notch3 expression levels in patients with bladder cancer.

Variables	n	Notch3 expressiona		P-value
		Low (n = 19)	High (n = 40)
Age (years)
< 50	2	1	1	0.544
≥ 50	57	18	39
Gender
Female	10	2	8	0.593
Male	49	17	32
Tumor stage
Ta	1	1	0	0.584
Tis	2	1	1
T1	12	5	7
T2	12	4	8
T3	20	5	15
T4	12	3	9
Tumor size (cm3)
< 5	39	13	26	0.795
≥ 5	20	6	14
Lymph node positivity
No	45	15	30	0.996
Yes	14	4	10
Distant metastasis
M0	59	19	40	---
Infiltration depth in bladder
Ta, T1, Tis	15	6	9
≥ T2	44	13	31
Histological grade
PUNLMP	8	4	4	0.291
Low	28	10	18
High	23	5	18

^aHigh = IRS of Notch3 expression > 4 points as assessed by immunohistochemistry; Low = IRS of Notch3 expression < 4 points (See Figure 2).

PUNLMP: papillary urothelial neoplasms of low malignant potential.