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. 2017 Mar 27;8(21):34552–34564. doi: 10.18632/oncotarget.16602

Figure 2. Cytotoxic effects of KPT-185 and AZD-2014 combination in primary MCL cells and not in normal hematopoietic stem cells.

Figure 2

Cells were treated by indicated concentrations of KPT-185, AZD-2014, or KPT-185+AZD-2014 (combination) for 24 hours. (A) Primary MCL cells from two patients were assessed by the trypan blue exclusion cell count method. (B) The annexin V positivity was measured by flow cytometry after electronic gating on CD34+ stem/progenitor hematopoietic cells from normal bone marrow mononuclear cells from three normal donors as described in Materials and Methods.