Table 2. Univariate and Multivariate analysis of clinical parameters in relation to progression-free survival.

Variables	Univariate		Multivariate
	HR (95%CI)	P	HR (95%CI)	P
High miR-590-3p expression	0.417 (0.327-0.841)	0.031*	0.514 (0.428-0.891)	0.012*
Clinicalstage at diagnosis	5.327 (2.594-9.442)	0.009*	4.978 (1.875-6.892)	0.0011*
Lymph node metastasis	2.217 (1.294-4.227)	0.022*	2.574 (1.442-3.908)	0.017*
Distant metastasis	3.532 (1.498-5.374)	0.014*	5.117 (1.915-8.162)	0.008*

CI: confidence interval; HR: hazard ratio;

*Significant relation of clinical parameters with progression-free survival