. 2017 Mar 29;8(21):34709–34726. doi: 10.18632/oncotarget.16671

Table 1. Observed responses of xenografts 8 days after treatment in the 2³ factorial design with three independent parameters and their two levels (GLUT-1 AS-ODNs and HIF-1α AS-ODNs 100 μg or 0 μg, X-ray irradiation 10 Gy or 0 Gy).

G	A (μg)	B (μg)	C (Gy)	Tumor weight^x (g)		AI (%)^x		MVD^x		Necrosis ratex (%)
G	A (μg)	B (μg)	C (Gy)	Hep-2	Tu212	Hep-2	Tu212	Hep-2	Tu212	Hep-2	Tu212
G1	100	100	10	0.36± 0.03	0.11 ± 0.01	47.71 ± 3.38	38.10 ± 0.41	3.67 ± 2.10	1.33 ± 0.66	51.67 ± 7.26	63.33 ± 3.33
G2	100	100	0	0.27 ± 0.08	0.13 ± 0.02	30.45 ± 2.51	31.66 ± 0.71	6.00 ± 1.10	6.33 ± 0.88	10.00 ± 2.88	23.33 ± 6.01
G3	0	100	10	0.57 ± 0.06	0.10 ±0.01	8.67 ± 1.35	9.70 ± 1.03	4.67 ± 0.88	4.33 ± 0.33	8.33 ± 1.66	23.33 ± 1.66
G4	100	0	10	0.41 ± 0.09	0.09 ± 0.01	14.04 ± 2.19	17.72 ± 1.41	11.33 ± 1.85	10.67 ± 1.33	10.00 ± 5.00	40.00 ± 2.88
G5	0	0	10	0.25 ± 0.03	0.11 ± 0.02	4.26 ± 0.53	5.68 ± 1.61	15.67 ± 1.76	12.00 ± 3.00	8.33 ± 1.66	35.00 ± 7.63
G6	0	100	0	0.21 ± 0.06	0.18 ± 0.06	6.07 ± 0.04	7.75 ± 1.05	13.00 ± 1.15	11.67 ± 1.76	5.00 ± 0.00	15.00 ± 5.00
G7	100	0	0	0.16 ± 0.01	0.13 ± 0.02	10.41 ± 0.51	14.85 ± 1.27	16.33 ± 2.18	18.33 ± 2.72	10.00 ± 2.88	5.00 ± 0.00
G8	0	0	0	0.33 ± 0.04	0.16 ± 0.04	2.24 ± 0.11	4.74 ± 1.28	34.00 ± 2.64	34.00 ± 3.05	1.66 ± 1.66	0.00 ± 0.00
a (p-value)				0.427	0.275	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
b (p-value)				0.09	0.711	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.591
c (p-value)				0.002	0.038	< 0.001	0.003	< 0.001	< 0.001	< 0.001	< 0.001
ab (p-value)				0.346	0.941	< 0.001	< 0.001	0.015	0.145	0.002	0.318
ac (p-value)				0.83	0.379	0.005	0.047	0.002	0.009	0.007	< 0.001
bc (p-value)				0.156	1.000	0.012	0.245	0.026	0.007	0.002	0.003
abc (p-value)				0.13	0.555	0.018	0.344	0.174	0.05	<0.001	0.004

G: group, A: GLUT-1 AS-ODNs, B: HIF-1α AS-ODNs, C: X-ray irradiation.

a: main effect of GLUT-1 AS-ONDs, b: main effect of HIF-1α AS-ODNs, c: main effect of X-ray irradiation, ab: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs, ac: interaction effect between GLUT-1 AS-ONDs and X-ray irradiation, bc: interaction effect between HIF-1α AS-ODNs and X-ray irradiation, abc: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs and X-ray irradiation.

^X Mean ± Std(standard deviation).

Table 1. Observed responses of xenografts 8 days after treatment in the 23 factorial design with three independent parameters and their two levels (GLUT-1 AS-ODNs and HIF-1α AS-ODNs 100 μg or 0 μg, X-ray irradiation 10 Gy or 0 Gy).

Table 1. Observed responses of xenografts 8 days after treatment in the 2³ factorial design with three independent parameters and their two levels (GLUT-1 AS-ODNs and HIF-1α AS-ODNs 100 μg or 0 μg, X-ray irradiation 10 Gy or 0 Gy).