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. 2017 Mar 29;8(21):34709–34726. doi: 10.18632/oncotarget.16671

Table 2. Observed responses of xenografts 12 days after treatment in the 23 factorial design with three independent parameters and their two levels (GLUT-1 AS-ODNs and HIF-1α AS-ODNs 100 μg or 0 μg, X-ray irradiation 10 Gy or 0 Gy).

G A (μg) B (μg) C (Gy) Tumor weightX (g) AI (%)X MVDX Necrosis rate (%)X
Hep-2 Tu212 Hep-2 Tu212 Hep-2 Tu212 Hep-2 Tu212
G1 100 100 10 0.14 ± 0.02 0.25 ± 0.04 14.33 ± 0.67 27.24 ± 0.36 2.33 ± 1.33 4.00 ± 0.57 56.67 ± 3.33 46.67 ± 6.66
G2 100 100 0 0.47± 0.02 0.21 ± 0.05 18.99 ± 1.13 17.19 ± 1.16 9.33 ± 0.33 10.00 ± 0.57 11.67 ± 3.33 36.67 ± 8.81
G3 0 100 10 0.42 ±0.12 0.30 ± 0.06 4.32 ± 0.03 6.42 ± 0.18 7.00 ± 1.00 7.66 ± 0.33 5.00 ± 0.00 40.00 ± 15.28
G4 100 0 10 0.26 ± 0.04 0.26 ± 0.05 4.82 ± 0.06 11.09 ± 0.30 16.67 ± 2.66 13.33 ± 0.88 10.00 ± 0.00 43.33 ± 8.18
G5 0 0 10 0.24 ± 0.04 0.33 ± 0.06 2.84 ± 0.15 3.88 ± 0.57 10.33 ± 1.20 14.00 ± 0.57 5.00 ± 0.00 23.33 ± 8.33
G6 0 100 0 0.53 ± 0.22 0.30 ±0.01 4.03 ± 0.18 5.78 ± 0.98 15.33 ± 0.88 16.00 ± 0.57 11.67 ± 3.33 16.67 ± 3.33
G7 100 0 0 0.60 ± 0.20 0.18 ± 0.04 8.24 ± 0.35 9.03 ± 0.49 25.33 ± 2.40 27.67 ± 1.45 5.00 ± 0.00 11.67 ± 1.66
G8 0 0 0 0.59 ± 0.02 0.42 ± 0.06 1.78 ± 0.21 2.73 ± 0.71 41.33 ± 1.45 45.00 ± 2.88 5.00 ± 0.00 5.00 ± 0.00
a (p-value) 0.952 0.006 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 1.000
b (p-value) 0.592 0.379 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.043
c (p-value) 0.022 0.837 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 1.000
ab (p-value) 0.051 0.292 < 0.001 < 0.001 < 0.001 0.032 < 0.001 0.018
ac (p-value) 0.134 0.140 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.205
bc (p-value) 0.873 0.767 0.173 < 0.001 < 0.001 < 0.001 < 0.001 0.162
abc (p-value) 0.826 0.356 0.747 < 0.001 < 0.001 < 0.001 < 0.001 0.041

G: group, A: GLUT-1 AS-ODNs, B: HIF-1α AS-ODNs, C: X-ray irradiation.

a: main effect of GLUT-1 AS-ONDs, b: main effect of HIF-1α AS-ODNs, c: main effect of X-ray irradiation, ab: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs, ac: interaction effect between GLUT-1 AS-ONDs and X-ray irradiation, bc: interaction effect between HIF-1α AS-ODNs and X-ray irradiation, abc: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs and X-ray irradiation.

X Mean ± Std(standard deviation).