Table 3. Observed GLUT-1 and HIF-1α expressions of xenografts 8 days after treatment in the 23 factorial design with three independent parameters and their two levels (GLUT-1 AS-ODNs and HIF-1α AS-ODNs 100 μg or 0 μg, X-ray irradiation 10 Gy or 0 Gy).
G | A (μg) | B (μg) | C (Gy) | GLUT-1mRNAX | Glut-1 proteinX | HIF-1α mRNAX | HIF-1α proteinX | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Hep-2 | Tu212 | Hep-2 | Tu212 | Hep-2 | Tu212 | Hep-2 | Tu212 | ||||
G1 | 100 | 100 | 10 | 0.15 ± 0.01 | 0.02 ± 0.01 | 0.32 ± 0.10 | 0.07 ± 0.03 | 0.36 ± 0.02 | 0.25 ± 0.03 | 0.36 ± 0.06 | 0.03 ± 0.00 |
G2 | 100 | 100 | 0 | 0.13 ± 0.01 | 0.03 ± 0.01 | 0.22± 0.11 | 0.07 ± 0.02 | 0.45 ± 0.05 | 0.40 ± 0.07 | 0.10 ± 0.05 | 0.06 ± 0.03 |
G3 | 0 | 100 | 10 | 0.71 ± 0.05 | 0.26 ± 0.03 | 0.85 ± 0.14 | 0.20 ± 0.09 | 0.45 ± 0.04 | 0.25 ± 0.05 | 0.60 ± 0.21 | 0.07 ± 0.03 |
G4 | 100 | 0 | 10 | 0.91 ± 0.08 | 0.12 ± 0.01 | 0.81 ± 0.20 | 0.09 ± 0.02 | 1.10 ± 0.09 | 0.59 ± 0.02 | 0.91 ± 0.08 | 0.11 ± 0.02 |
G5 | 0 | 0 | 10 | 1.09 ± 0.09 | 0.49 ± 0.07 | 0.67 ± 0.21 | 0.45 ± 0.03 | 1.18 ± 0.16 | 0.67 ± 0.05 | 0.63 ±0.12 | 0.22 ± 0.04 |
G6 | 0 | 100 | 0 | 0.34 ± 0.02 | 0.22 ± 0.05 | 0.14 ± 0.09 | 0.22 ±0.06 | 0.27 ± 0.01 | 0.34 ± 0.01 | 0.13 ± 0.02 | 0.10 ± 0.07 |
G7 | 100 | 0 | 0 | 0.20 ±0.02 | 0.11 ± 0.02 | 0.37 ± 0.06 | 0.11 ± 0.03 | 0.95 ± 0.06 | 0.92 ± 0.04 | 0.63 ± 0.14 | 0.17 ± 0.09 |
G8 | 0 | 0 | 0 | 1.00 ± 0.08 | 1.02 ± 0.15 | 1.07 ± 0.07 | 0.84 ± 0.09 | 1.01± 0.07 | 1.02 ± 0.14 | 0.86 ± 0.07 | 0.29 ± 0.06 |
a (p-value) | < 0.001 | < 0.001 | 0.018 | < 0.001 | 0.639 | 0.510 | 0.509 | 0.121 | |||
b (p-value) | < 0.001 | < 0.001 | 0.002 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.003 | |||
c (p-value) | < 0.001 | 0.012 | 0.043 | 0.014 | 0.127 | < 0.001 | 0.028 | 0.326 | |||
ab (p-value) | 0.128 | < 0.001 | 0.789 | < 0.001 | 0.238 | 0.212 | 0.331 | 0.547 | |||
ac (p-value) | 0.092 | 0.013 | 0.567 | 0.025 | 0.275 | 0.755 | 0.382 | 0.783 | |||
bc (p-value) | 0.048 | 0.007 | 0.063 | 0.03 | 0.401 | 0.026 | 0.051 | 0.750 | |||
abc (p-value) | < 0.001 | < 0.01 | 0.002 | 0.041 | 0.202 | 0.680 | 0.002 | 0.805 |
G: group, A: GLUT-1 AS-ODNs, B: HIF-1α AS-ODNs, C: X-ray irradiation.
a: main effect of GLUT-1 AS-ONDs, b: main effect of HIF-1α AS-ODNs, c: main effect of X-ray irradiation, ab: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs, ac: interaction effect between GLUT-1 AS-ONDs and X-ray irradiation, bc: interaction effect between HIF-1α AS-ODNs and X-ray irradiation, abc: interaction effect between GLUT-1 AS-ONDs and HIF-1α AS-ODNs and X-ray irradiation.
X Mean ± Std(standard deviation).