Table 3. Incidence density rates and hazard ratios of osteoporosis and fracture in patients with and without HSCT stratified by sex, age, comorbidity, and underlying cancers.
| Non-HSCT group | HSCT group | HR (95% CI) | P for interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Event no. | Person-years | IR | Event no. | Person-years | IR | Crude | Adjusteda | ||
| Osteoporosis | |||||||||
| Sex | 0.91 | ||||||||
| Women | 74 | 8915 | 8.30 | 27 | 1500 | 18.0 | 2.10 (1.35–3.27)** | 2.59 (1.64–4.09)*** | |
| Men | 51 | 13,199 | 3.86 | 20 | 2275 | 8.79 | 2.21 (1.31–3.70)** | 2.58 (1.51–4.41)*** | |
| Age of HSCT (year) | 0.003 | ||||||||
| < 18 | 8 | 6307 | 1.27 | 5 | 576 | 8.68 | 5.69 (1.84–17.5)** | 5.33 (1.70–16.7)** | |
| 18–50 | 40 | 11162 | 3.58 | 31 | 2616 | 11.9 | 3.33 (2.08–5.32)*** | 3.45 (2.15–5.55)*** | |
| > 50 | 77 | 4646 | 16.6 | 11 | 582 | 18.9 | 1.10 (0.59–2.06) | 1.10 (0.58–2.10) | |
| Comorbidity† | 0.12 | ||||||||
| No | 58 | 16,854 | 3.44 | 27 | 2601 | 10.4 | 2.94 (1.86–4.64)*** | 2.92 (1.84–4.63)*** | |
| Yes | 67 | 5260 | 12.7 | 20 | 1173 | 17.1 | 1.34 (0.82–2.22) | 2.02 (1.19–3.42)** | |
| Type of cancer | 0.10 | ||||||||
| Hematologic malignancy | 115 | 19824 | 5.80 | 38 | 3407 | 11.2 | 1.86 (1.29–2.68)** | 2.32 (1.59–3.40)*** | |
| Solid tumor | 10 | 2290 | 4.37 | 9 | 368 | 24.5 | 5.85 (2.36–14.5)*** | 5.92 (2.34–15.0)*** | |
| Fracture | |||||||||
| Sex | 0.13 | ||||||||
| Women | 28 | 9107 | 3.07 | 6 | 1596 | 3.76 | 1.21 (0.50–2.92) | 1.51 (0.61–3.74) | |
| Men | 26 | 13,276 | 1.96 | 13 | 2293 | 5.67 | 2.78 (1.43–5.43)** | 3.21 (1.62–6.37)*** | |
| Age of HSCT (year) | 0.62 | ||||||||
| < 18 | 5 | 6313 | 0.79 | 2 | 5873 | 3.41 | 3.47 (0.66–18.2) | 3.41 (0.63–18.5) | |
| 18–50 | 19 | 11259 | 1.69 | 11 | 2707 | 4.06 | 2.46 (1.17–5.17)* | 2.68 (1.26–5.72)* | |
| > 50 | 30 | 4811 | 6.24 | 6 | 595 | 10.1 | 1.53 (0.64–3.67) | 1.64 (0.67–4.02) | |
| Comorbidityb | 0.79 | ||||||||
| No | 28 | 16,983 | 1.65 | 10 | 2687 | 3.72 | 2.34 (1.09–4.61)* | 2.26 (1.09–4.69)* | |
| Yes | 26 | 5400 | 4.81 | 9 | 1203 | 7.48 | 1.52 (0.71–3.25) | 1.94 (0.88–4.28) | |
| Type of cancer | 0.11 | ||||||||
| Hematologic malignancy | 49 | 20087 | 2.44 | 14 | 3504 | 3.99 | 1.58 (0.87–2.87) | 1.90 (1.03–3.50)* | |
| Solid tumor | 5 | 2297 | 2.18 | 5 | 385 | 13.0 | 6.26 (1.80–21.7)** | 5.79 (1.67–20.1)** | |
HSCT: hematopoietic stem cell transplant; IR: incidence density rate per 1000 person-years; HR: hazard ratio; CI: confidence interval.
aModel mutually adjusting for sex, age, diabetes mellitus, hyperlipidemia, hypertension, coronary artery disease, depression, stroke, chronic obstructive pulmonary disease, chronic kidney disease, and the type of cancer.
bIncluding diabetes mellitus, hyperlipidemia, hypertension, coronary artery disease, depression, stroke, chronic obstructive pulmonary disease, and chronic kidney disease.
*P < 0.05, **P < 0.01, ***P < 0.001.