. 2017 Mar 31;8(21):34820–34835. doi: 10.18632/oncotarget.16747

Table 3. Association between molecular and serologic markers of human papillomavirus 16 infections and 5-year local recurrences.

Variable^a	Number of Local recurrences	AUC of time-dependent ROC^b	Local recurrence (n = 21)
Variable^a	Number of Local recurrences	AUC of time-dependent ROC^b	Univariate analysis^c	P value	Multivariate analysis^d	P value
E6/E7 mRNA		0.500
Negative (75 [88])	16		Reference		Reference
Positive (10 [12])	5		3.6 (1.3−10.0)	0.014	6.4 (2.0−20.0)	0.001
Anti-L1 antibodies		0.486
≤ 876 (68 [80])	17		Reference		Reference
> 876 (17 [20])	4		1.3 (0.4−3.8)	0.678	−	NA
Anti-E6 antibodies		0.369
≤ 678 (50 [59])	17		Reference		Reference
> 678 (35 [41])	4		0.3 (0.1−0.98)	0.047	0.2 (0.1−0.5)	0.003
Anti-E7 antibodies		0.512
≤ 948 (26 [31])	5		Reference		Reference
> 948 (59 [69])	16		1.6 (0.6−4.3)	0.389	3.9 (1.3−11.7)	0.014

AUC, area under the curve; NA, not available; NS, not significant; ROC, receiver operating characteristic.

^aData are expressed as counts (%).

^bData are calculated based on ungrouped baseline data.

^cData are expressed as hazard ratios (95% confidence intervals) calculated with Cox regression models.

^dData are expressed as hazard ratios (95% confidence intervals) calculated with Cox regression models with a non-parametric 95% bootstrap confidence interval (200 runs). Significant P values are marked in bold.