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. 2017 Apr 4;8(21):34867–34883. doi: 10.18632/oncotarget.16802

Figure 8. Sponged miR-09-3-5P expression promoted lymph node metastasis in vivo.

Figure 8

(A) The popliteal lymph node metastasis model was built by injecting the foot pad of nude mice with MGC803/mock, MGC803/RV-negative control (NC) and MGC803/RV-miR-509-3-5P/sponge cells. (B) Representative photograph of lymph nodes from nude mice dissected 4 weeks later after inoculation in foot pad. (C) Representative image of popliteal lymph nodes stained with anti-E-cadherin antibody. The upper panel was shown in 200×, the lower panel was shown in 400×. (D) The level of MLD marked by Lyve-1 in MGC803/RV-miR-509-3-5P/sponge group was higher than the rest two groups. (E) The left table showed the metastatic ratio of all dissected popliteal lymph nodes of nude mice. The right graph represented for the level of microlymphatic vessel density (MLD) in the tumor of three groups (*p < 0.05, **p < 0.01).