Figure 6. In vivo analysis of JIB 04.

(Panel A) M Pharmacokinetics of JIB-04: extracted ion current of m/z 309.09 [M+H]⁺ in plasma and brain extracts of mice treated for 5 days with 60 mg/kg of JIB 04. The presence of an identical peak corresponding to JIB 04 (see Supplementary Figure 5) in the two extracts indicates the passage of the molecule through the blood brain barrier. (Panel B) Kaplan-Maier plots of 10 mice orthotopically xenografted with DBTRG cells treated with JIB 04 (N: 5) or with placebo (N: 5). The hazard ratio of the mice treated with JIB 04 is 0.5.