Table 1. Clinicopathologic and molecular characteristics in 84 colorectal MACs with and without SAC morphology.
| Characteristic | MAC withoutSAC morphology(n=52)a | MAC with SACmorphology(n=32)b | P-value |
|---|---|---|---|
| Gender | 0.255 | ||
| Male | 31 (59.6) | 15 (46.9) | |
| Female | 21 (40.4) | 17 (53.1) | |
| Age | 0.157 | ||
| ≤ 70 years | 31 (59.6) | 14 (43.8) | |
| > 70 years | 21 (40.4) | 18 (56.3) | |
| Location | 0.001 | ||
| Proximal colon | 18 (34.6) | 23 (71.9) | |
| Distal colon or rectum | 34 (65.4) | 9 (28.1) | |
| Differentiation | 0.952 | ||
| Well | 9 (17.3) | 5 (15.6) | |
| Moderate | 36 (69.2) | 22 (68.8) | |
| Poor | 7 (13.5) | 5 (15.6) | |
| AJCC TNM stage | 0.889 | ||
| Stage I | 2 (3.8) | 1 (3.1) | |
| Stage II | 22 (42.3) | 14 (43.8) | |
| Stage III | 21 (40.4) | 11 (34.4) | |
| Stage IV | 7 (13.5) | 6 (18.8) | |
| KRAS mutation (n=75) | 19 (42.2) | 13 (43.3) | 0.924 |
| BRAF mutation (n=73) | 3 (7) | 8 (26.7) | 0.042 |
| CIMP positive (n=77) | 3 (6.5) | 8 (25.8) | 0.023 |
| Defective mismatch repair protein | 12 (23.1) | 7 (21.9) | 0.898 |
AJCC, American Joint Committee on Cancer; CIMP, CpG island methylator phenotype; MAC, mucinous adenocarcinoma; SAC, serrated adenocarcinoma.
a Values are calculated for 52 MACs without SAC morphology unless specified otherwise, and are presented as number and percentage of patients.
b Values are calculated for 32 MACs with SAC morphology unless specified otherwise, and are presented as number and percentage of patients.