Fig. 6.

Organization of COLLs-, TNs- and FN-ECM, and α2β1 and α5β1 integrin receptors. Control and GalT-II-deficient (P1 and P2) skin fibroblasts were analyzed with specific Abs directed against COLLI, COLLIII, and COLLV. TNs and FN were investigated by labeling the cells with Abs recognizing all TN and FN isoforms. The COLL- and FN-specific receptors, α2β1 and α5β1 integrins, respectively, were analyzed with two specific mAbs recognizing their ligand-binding sites. Scale bar: 10 μm. Experiments were repeated three times. Representative images are shown.