Table 1.
Selection of the most up- and down-regulated DEGs identified in GalT-II-deficient skin fibroblasts.
| Gene description | Gene symbol | Fold-change | P-value |
|---|---|---|---|
| Up-regulated genes | |||
| STEAP family member 4 | STEAP4 | 41.6 | 0.0004 |
| Sema domain, immunoglobulin domain (Ig), short basic domain, secreted 3A | SEMA3A | 15.6 | 0.01 |
| ATP-binding cassette, sub-family A (ABC1), member 8 | ABCA8 | 12.5 | 0.03 |
| Aquaporin 9 | AQP9 | 10.3 | 0.001 |
| Immunoglobulin superfamily, member 10 | IGSF10 | 8.6 | 0.003 |
| Tumor necrosis factor (ligand) superfamily, member 10 | TNFSF10 | 8.6 | 0.007 |
| Elav-like family member 2 | CELF2 | 8.0 | 0.02 |
| Alcohol dehydrogenase 1B (class I), beta polypeptide | ADH1B | 7.6 | 0.01 |
| Insulin-like growth factor binding protein 2 | IGFBP2 | 7.6 | 0.02 |
| Relaxin/insulin-like family peptide receptor 1 | RXFP1 | 6.7 | 0.02 |
| Interleukin 13 receptor, alpha 2 | IL13RA2 | 6.7 | 0.004 |
| Hyaluronan synthase 2 | HAS2 | 6.6 | 0.002 |
| Cytochrome P450, family 19, subfamily A, polypeptide 1 | CYP19A1 | 6.1 | 0.006 |
| Junctional adhesion molecule 2 | JAM2 | 6.0 | 0.007 |
| Collagen and calcium binding EGF domains 1 | CCBE1 | 5.5 | 0.01 |
| Chondroitin sulfate N-acetylgalactosaminyltransferase 1 | CSGALNACT1 | 4.7 | 0.01 |
| Peroxisome proliferator-activated receptor gamma | PPARG | 4.5 | 0.003 |
| Endothelin receptor type B | EDNRB | 4.4 | 0.001 |
| Polypeptide N-acetylgalactosaminyltransferase 16 | GALNTL1 | 3.4 | 0.04 |
| Down-regulated genes | |||
| LIM homeobox 9 | LHX9 | − 14.5 | 0.01 |
| Tumor necrosis factor (ligand) superfamily, member 4 | TNFSF4 | − 11.8 | 0.003 |
| Oxytocin receptor | OXTR | − 10.4 | 0.002 |
| Hairy and enhancer of split 1, (Drosophila) | HES1 | − 9.7 | 0.01 |
| Cartilage oligomeric matrix protein | COMP | − 9.1 | 0.004 |
| Phosphodiesterase 1C, calmodulin-dependent | PDE1C | − 8.9 | 0.004 |
| Nuclear receptor subfamily 4, group A, member 2 | NR4A2 | − 8.0 | 0.01 |
| Potassium voltage-gated channel, KQT-like subfamily, member 5 | KCNQ5 | − 7.9 | 0.02 |
| Mohawk homeobox | MKX | − 7.3 | 0.0007 |
| Cholinergic receptor, muscarinic 2 | CHRM2 | − 6.8 | 0.01 |
| Homeobox D10 | HOXD10 | − 6.8 | 0.02 |
| Cadherin 13, H-cadherin (heart) | CDH13 | − 4.2 | 0.005 |
| Transcription factor AP-2 alpha | TFAP2A | − 4.1 | 0.01 |
| Dickkopf homologue 3 (Xenopus laevis) | DKK3 | − 4.0 | 0.008 |
| Secreted frizzled-related protein 4 | SFRP4 | − 4.0 | 0.03 |
| Lysyl oxidase-like 3 | LOXL3 | − 3.6 | 0.02 |
| Collagen, type XV, alpha 1 | COL15A1 | − 3.6 | 0.005 |
| Matrix metallopeptidase 16 (membrane-inserted) | MMP16 | − 3.5 | 0.02 |
| Short stature homeobox | SHOX | − 3.3 | 0.01 |
| Sparc/osteonectin, cwcv and kazal-like domains proteoglycan | SPOCK1 | − 3.3 | 0.001 |
| Wingless-type MMTV integration site family, member 5A | WNT5A | − 3.3 | 0.03 |
| Homeobox D11 | HOXD11 | − 3.2 | 0.01 |