Table 4.

Selection of DAVID functional annotation clusters obtained with the down-regulated genes.

Cluster	Enrichment score	Category	Term	P-value
1	4.8	SP_PIR_KEYWORDS	Glycoprotein	1.35E-10
		UP_SEQ_FEATURE	Signal peptide	3.22E-07
		GOTERM_CC_FAT	GO:0005576—extracellular region	2.82E-04
2	3.1	GOTERM_BP_FAT	GO:0001501—skeletal system development	9.91E-05
		GOTERM_BP_FAT	GO:0060173—limb development	2.66E-04
		GOTERM_BP_FAT	GO:0048598—embryonic morphogenesis	0.005
3	2.6	UP_SEQ_FEATURE	Glycosylation site:N-linked (GlcNAc…)	7.53E-10
		GOTERM_CC_FAT	GO:0044459—plasma membrane part	0.001
		UP_SEQ_FEATURE	Topological domain:extracellular	0.005
4	2.46	GOTERM_MF_FAT	GO:0003700—transcription factor activity	6.84E-04
		GOTERM_MF_FAT	GO:0043565—sequence-specific DNA binding	0.001
		INTERPRO	IPR001356:homeobox	0.01
5	2.45	GOTERM_BP_FAT	GO:0060284—regulation of cell development	7.11E-05
		GOTERM_BP_FAT	GO:0045596—negative regulation of cell differentiation	0.002
		GOTERM_BP_FAT	GO:0051960—regulation of nervous system development	0.006
6	2.0	GOTERM_MF_FAT	GO:0030528—transcription regulator activity	2.91E-04
		GOTERM_MF_FAT	GO:0003677—DNA binding	0.04
		SP_PIR_KEYWORDS	Transcription regulation	0.03
7	1.98	GOTERM_BP_FAT	GO:0042325—regulation of phosphorylation	0.002
		GOTERM_BP_FAT	GO:0043549—regulation of kinase activity	0.03
		GOTERM_BP_FAT	GO:0031399—regulation of protein modification process	0.04
8	1.96	GOTERM_BP_FAT	GO:0042981—regulation of apoptosis	0.009
		GOTERM_BP_FAT	GO:0043066—negative regulation of apoptosis	0.011
9	1.87	GOTERM_BP_FAT	GO:0016481—negative regulation of transcription	0.006
		GOTERM_BP_FAT	GO:0016564—transcription repressor activity	0.013
10	1.54	GOTERM_BP_FAT	GO:0030182—neuron differentiation	0.0014
		GOTERM_BP_FAT	GO:0048812—neuron projection morphogenesis	0.037
11	1.46	INTERPRO	IPR000742:EGF-like, type 3	0.018
		SP_PIR_KEYWORDS	egf-like domain	0.025