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. 2017 Jun 14;7:3493. doi: 10.1038/s41598-017-03728-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RAD001 decreases tumour vasculature in mouse model of human prostate cancer. Subcutaneous PC3 tumours were established in nude mice as described in materials and methods and allowed to grow for two weeks. Mice were treated with sham (Cont), 5 mg/kg RAD001 (RAD), 5 mg/kg docetaxel (Doc) and combination of these drugs (RAD + Doc) for three weeks. (A) Representative images of subcutaneous human tumours in mice after corresponding treatments. (B) Tumour volumes at week five. (C) P70S6K phosphorylation in tumours was measured using ELISA. (D–F) Human SK1 (D), VEGF (E) and mouse CD31 (F) expression was determined by qRT-PCR. Columns, mean values of n = 8; bars, SEM. (^*P < 0.05; ^**P < 0.01; ^§P < 0.001; ns, not significant, P > 0.05).