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. 2017 Jun 14;7:3451. doi: 10.1038/s41598-017-03759-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Leptin has no effect on IL-6 secretion from synovial fibroblasts, but does affect IL-6 secretion from chondrocytes. (A) Secretion of IL-6 in synovial fibroblasts following stimulation with 500 ng/ml leptin. (B) Secretion of IL-6 from chondrocytes stimulated with 500 ng/ml leptin. (C) Synovial fibroblasts cultured in leptin-stimulated chondrocyte conditioned media show enhanced IL6 secretion. IL6 expression was determined by ELISA. Data are mean ± SEM. Statistical significance was determined by Mann-Whitney U test and One-Way ANOVA where *p < 0.05, ***p < 0.001.