. 2017 Jun 14;7:3451. doi: 10.1038/s41598-017-03759-w

Table 1.

The impact of obesity on T cell subsets in the peripheral blood and bone marrow of OA patients.

	Normal weight (BMI 18.5–24.9)		Obese (BMI ≥ 30.0)
	PB	BM	PB	BM
CD4:CD8 ratio	2.7 ± 0.8	0.7 ± 0.1	2.9 ± 0.6	1.4 ± 0.3
*CD4* ⁺ *T cells*
% T_N	45.5 ± 6.6	25.8 ± 5.8	43.3 ± 3.8	31.4 ± 4.3
% T_CM	34.3 ± 3.6	31 ± 5	40.9 ± 3.2	33.7 ± 2.7
% T_EM	14.1 ± 4.3	38.9 ± 4.8	13.9 ± 1.8	32.3 ± 3.4
% T_EMRA	5.4 ± 1.2	4.3 ± 1	3.3 ± 1.2	2.7 ± 0.4
% CD28⁻	1.5 ± 0.6	1.7 ± 0.4	1.1 ± 0.4	1.3 ± 0.4
% CD69⁺	0.2 ± 0.1	15.3 ± 1.9	0.4 ± 0.2	15.2 ± 2.5
% T_reg	3 ± 0.4	3.3 ± 0.7	3.5 ± 0.9	3 ± 0.4
% IFN-γ⁺	19.2 ± 3.4	31.7 ± 6	10.1 ± 1.9	21.2 ± 6.2
% IL-4⁺	3.7 ± 1.1	3.4 ± 0.9	2.4 ± 0.7	1.6 ± 0.7
% IL-2⁺	59.7 ± 5.1	47.4 ± 8.7	55.1 ± 5.7	32.5 ± 8.3
% IL-10⁺	0.38 ± 0.06	1.6 ± 0.6	0.29 ± 0.05	1.7 ± 0.2
% IL-17A⁺	0.34 ± 0.11	0.67 ± 0.32	0.77 ± 0.12	1.14 ± 0.16
% IL-17A⁺ IFN-γ⁺	0.01 ± 0.004	0.14 ± 0.06	0.09 ± 0.05	0.39 ± 0.08
% polyfunctional	10.9 ± 1.3	19.8 ± 4.2	6.3 ± 1.3	10.8 ± 6.6
*CD8* ⁺ *T cells*
% T_N	14.8 ± 5.5	6.3 ± 0.9	12.3 ± 2.4	8.6 ± 1.3
% T_CM	15.3 ± 2.6	12.3 ± 3.9	19.9 ± 3.9	14 ± 1.7
% T_EM	37.2 ± 6.1	51.6 ± 2.4	38.2 ± 7.2	50.5 ± 3.9
% T_EMRA	32.7 ± 4.5	29.7 ± 5	29.6 ± 4.6	26.9 ± 3.4
% CD28⁻	46.7 ± 9.8	32.5 ± 4.1	43.2 ± 10.5	32.3 ± 6.1
% CD28⁻ CD57⁺	28.1 ± 10.8	6.5 ± 3.1	33.5 ± 8.9	11.5 ± 4.9
% CD69⁺	1.1 ± 0.3	44.4 ± 5.8	1.5 ± 0.3	52.1 ± 5.6
% IFN-γ⁺	47.8 ± 10.4	54 ± 9.6	49.7 ± 9.5	64.2 ± 11.3
% IL-2⁺	22.1 ± 6.6	21.4 ± 7.1	19.6 ± 5.5	22.1 ± 7.6
% polyfunctional	13.9 ± 2.8	19.3 ± 4.3	11 ± 3.5	22.9 ± 1.6

Data are expressed as mean ± SEM. T_reg cells were defined as CD25^hi CD127^dim cells. Polyfunctionality was defined as cells that simultaneously produced IFN-γ, TNF-α and IL-2. PB = peripheral blood; BM = bone marrow.